Blood pressure regulation and sup 45 Ca flux in aging Zucker rats

Conference · Mon Feb 26 04:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:6057176

Zemel, M B; Shehin, S E; Chiou, S Y; Sowers, J R ^[1]

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1. Wayne State Univ., Allen Park, MI (United States) Veterans Administration Medical Center, Allen Park, MI (United States)

The authors have previously reported that Zucker obese rats exhibit significant hypertension associated with an impairment in vascular smooth muscle Ca{sup 2+} efflux compared to their lean controls. To further investigate this phenomenon, the authors measured direct intra-arterial blood pressure in previously cannulated, unrestrained, conscious Zucker lean and obese rats at 10 weeks of age and 60 weeks of age. The animals were sacrificed and replicate aortic strips from each were loaded with {sup 45}Ca and {sup 45}Ca efflux was evaluated. Results show that both young and old obese rats exhibit systolic and diastolic hypertension and impaired Ca{sup 2+} efflux, and these defects were exaggerated in the old animals. Further, the old lean animals exhibited diastolic hypertension and impaired Ca{sup 2+} efflux comparable to that found in the young obese animals. This suggests that old Zucker lean rats exhibit the same defects in Ca{sup 2+} efflux comparable to that found in the young obese animals. This suggests that old Zucker lean rats exhibit the same defects in Ca{sup 2+} metabolism previously observed in young Zucker obese rats, possibly due to latent gene expression of the Fa gene in heterozygous lean rats.

• OSTI ID: 6057176
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 4:3
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADULTS
AGE DEPENDENCE
AGE GROUPS
AGED ADULTS
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CALCIUM 45
CALCIUM COMPOUNDS
CALCIUM ISOTOPES
CARDIOVASCULAR DISEASES
CATIONS
CHARGED PARTICLES
DAYS LIVING RADIOISOTOPES
DISEASES
ETIOLOGY
EVEN-ODD NUCLEI
GENES
HYPERTENSION
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLISM
NUCLEI
RADIOISOTOPES
RATS
RODENTS
SYMPTOMS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES