Fate of the 8,9-Z isomer of avermectin B sub 1a rats
- Merck, Sharp and Dohme Research Lab., Three Bridges, NJ (United States)
The 8,9-Z isomer of avermectin B{sub 1a} is formed photolytically in the environment and on various crops after treatment with avermectin. Male rats were orally administered a single dose of 1.4 mg/kb {sup 3}H-8,9-Z isomer of avermectin B{sub 1a} (8,9-Z-B{sub 1a}), and radioactive residues in the tissues and excreta were determined 1, 2, 4 and 7 days postdose. The initial residue in tissues was {lt}1.5 ppm and essentially depleted within 7 days postdose. The depletion half-life of the total residue was approximately 1.5 days for liver, kidney, muscle, and fat. Most of the dose (99%) was recovered in the feces with {lt}1% found in the urine. Unchanged 8,9-Z-B{sub 1a} levels in the liver tissue were 91 and 50% for 1 and 7 days postdose, respectively. The depletion half-life of the 8,9-Z-B{sub 1a} in the liver tissues was 1.2 days. Two metabolites were identified in the liver, kidney, muscle and fat. These two metabolites and the 8,9-Z-B{sub 1a} accounted for 92-98% of the total tissue residue. The fate of 8,9-Z isomer of avermectin B{sub 1a} was similar to the fate of avermectin B{sub 1a} rats.
- OSTI ID:
- 6056873
- Journal Information:
- Journal of Agricultural and Food Chemistry; (United States), Journal Name: Journal of Agricultural and Food Chemistry; (United States) Vol. 37:6; ISSN JAFCA; ISSN 0021-8561
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
FECES
GLANDS
HYDROGEN COMPOUNDS
INSECTICIDES
ISOTOPE APPLICATIONS
KIDNEYS
LIVER
MAMMALS
MATERIALS
METABOLISM
MUSCLES
ORAL ADMINISTRATION
ORGANS
PESTICIDES
RATS
RODENTS
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
URINE
VERTEBRATES
WASTES