Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer

Journal Article · Wed May 01 04:00:00 EDT 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.9.3847· OSTI ID:6055936

Chen, Ling-Chun; Kurisu, W; Smith, H S ^[1]; Neubauer, A; Liu, E ^[2]; Waldman, F M; Ljung, B M; Goodson, W III; Goldman, E S; Balazs, M; Mayall, B H ^[3]; Moore, D II ^[4]

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1. Pacific Presbyterian Medical Center, San Francisco, CA (United States)
2. Univ. of North Carolina, Chapel Hill (United States)
3. Univ. of California, San Francisco (United States)
4. Lawrence Livermore Lab., CA (United States)

Loss of heterozygosity (LOH) on the short arm of chromosome 17 (17p) was found in 27 of 52 (52%) previously untreated primary breast cancers. There was a significant correlation between this 17p allelic loss and two parameters associated with aggressive tumor behavior: high cellular proliferative fraction and DNA aneuploidy. These correlations with high cellular proliferative fraction and DNA aneuploidy were not found in tumors with LOH at nine other chromosome locations. The p53 gene, a putative tumor suppressor gene located at 17p13, was examined for aberrations to determine whether it is the target for the 17p LOH in breast cancer. Unlike other types of human cancer, there were no homozygous deletions or rearrangements of the p53 gene, and only 2 of 13 (15%) were mutated in the conserved region where mutational hot spots have been previously located. Therefore, the authors hypothesize that, in breast cancer, either loss of inactivation of gene(s) on chromosome 17p other than the p53 gene or a different mechanism of p53 gene inactivation may be responsible for the observed mechanism high labeling index and DNA aneuploidy associated with LOH at 17p.

• OSTI ID: 6055936
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 88:9; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANEUPLOIDY
ANIMAL CELLS
AUTORADIOGRAPHY
BODY
CARCINOMAS
CELL PROLIFERATION
CHROMOSOMES
DISEASES
FLUORESCENCE
GENES
GLANDS
HUMAN CHROMOSOME 17
HUMAN CHROMOSOMES
INACTIVATION
LUMINESCENCE
MAMMARY GLANDS
NEOPLASMS
ORGANS
PLOIDY
TUMOR CELLS