Gallium uptake in tryptophan-related pulmonary disease

Journal Article · Fri Feb 01 00:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:6055684

Kim, S M; Park, C H; Intenzo, C M; Patel, R ^[1]

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1. Thomas Jefferson Univ. Hospital, Philadelphia, PA (USA)

We describe a patient who developed fever, fatigue, muscle weakness, dyspnea, skin rash, and eosinophilia after taking high doses of tryptophan for insomnia for two years. A gallium-67 scan revealed diffuse increased uptake in the lung and no abnormal uptake in the muscular distribution. Bronchoscopy and biopsy confirmed inflammatory reactions with infiltration by eosinophils, mast cells, and lymphocytes. CT scan showed an interstitial alveolar pattern without fibrosis. EMG demonstrated diffuse myopathy. Muscle biopsy from the right thigh showed an inflammatory myositis with eosinophilic and lymphocytic infiltrations.

• OSTI ID: 6055684
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 32:2; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GALLIUM 67
UPTAKE
RESPIRATORY SYSTEM DISEASES
DIAGNOSIS
TRYPTOPHAN
BIOLOGICAL EFFECTS
COMPUTERIZED TOMOGRAPHY
PATIENTS
SYMPTOMS
AMINO ACIDS
AROMATICS
AZAARENES
AZOLES
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INTERMEDIATE MASS NUCLEI
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRROLES
RADIOISOTOPES
TOMOGRAPHY
550601* - Medicine- Unsealed Radionuclides in Diagnostics