Inhibition of vitamin B12-dependent microbial growth by nitrous oxide
Journal Article
·
· Life Sciences; (USA)
- Massachusetts General Hospital, Boston (USA)
In methionine-free media, nitrous oxide inhibits the growth of an auxotrophic strain of Escherichia coli lacking a cobalamin-independent pathway for the de novo synthesis of methionine. Prototrophic E. coli is similarly inhibited by nitrous oxide if the cobalamin-independent pathway is selectively depressed by sulfanilamide. Nitrous oxide thus effectively inactivates cobalamin-dependent 5-methyltetrahydrofolate-homocysteine methyltransferase in intact bacteria.
- OSTI ID:
- 6055480
- Journal Information:
- Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 48:16; ISSN 0024-3205; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
CARBOXYLIC ACIDS
CHALCOGENIDES
DRUGS
ESCHERICHIA COLI
GROWTH
HEMATINICS
HEMATOLOGIC AGENTS
INHIBITION
LIPOTROPIC FACTORS
METHIONINE
MICROORGANISMS
NITROGEN COMPOUNDS
NITROGEN OXIDES
NITROUS OXIDE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
VITAMIN B GROUP
VITAMIN B-12
VITAMINS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BACTERIA
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
CARBOXYLIC ACIDS
CHALCOGENIDES
DRUGS
ESCHERICHIA COLI
GROWTH
HEMATINICS
HEMATOLOGIC AGENTS
INHIBITION
LIPOTROPIC FACTORS
METHIONINE
MICROORGANISMS
NITROGEN COMPOUNDS
NITROGEN OXIDES
NITROUS OXIDE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
VITAMIN B GROUP
VITAMIN B-12
VITAMINS