Antimutagenic activities of naturally occurring polyamines in Chinese hamster ovary cell in vitro

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Environmental and Molecular Mutagenesis; (United States)

DOI:https://doi.org/10.1002/em.2850180308· OSTI ID:6053696

Cozzi, R; Perticone, P; Bona, R; Polani, S ^[1]

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1. Univ. La Sapienza, Rome (Italy)

Spermine and spermidine, ubiquitous polyamines present in bacteria and animal cells, are also involved in cell growth. Since they interact with the double helix, they can stabilize the DNA molecule. Recent evidence of the antimutagenic and anticarcinogenic capacity of spermine has focused attention on the he mechanism(s) by which such agents can protect cells from induced damages. In the present paper the authors show the ability of spermine and spermidine to decrease the level of sister chromatid exchanges induced in Chinese hamster ovary cells cultivated in vitro, by treating them with Psoralen + UVA irradiation (able to induce mainly monoadducts and DNA cross-links). Two different mechanisms of polyamine action can be invoked to explain the preservative activity of this class of agents.

• OSTI ID: 6053696
• Journal Information: Environmental and Molecular Mutagenesis; (United States), Journal Name: Environmental and Molecular Mutagenesis; (United States) Vol. 18:3; ISSN EMMUE; ISSN 0893-6692
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANTICOAGULANTS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHO CELLS
CHROMOSOMAL ABERRATIONS
COUMARINS
DRUGS
ELECTROMAGNETIC RADIATION
EXTREME ULTRAVIOLET RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MUTATION FREQUENCY
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PSORALEN
RADIATION EFFECTS
RADIATIONS
SISTER CHROMATID EXCHANGES
SPERMIDINE
SPERMINE
ULTRAVIOLET RADIATION