(/sup 125/I) 3-Quinuclidinyl 4-iodobenzilate: a high affinity, high specific activity radioligand for the M/sub 1/ and M/sub 2/-acetylcholine receptors
Journal Article
·
· Life Sci.; (United States)
A radioiodinated ligand has been prepared which binds with high affinity to the muscarinic acetylcholine receptor (m-AChR). A derivative of 3-quinuclidinyl benzilate, (/sup 125/I) labeled (R) 1-azabicyclo(2.2.2)oct-3-yl (R,S)-..cap alpha..-hydroxy-..cap alpha..-(4-(/sup 125/I)iodophenyl)phenyl acetate (4-IQNB) exhibits an affinity for the m-AChR from corpus striatum higher than that of (R) (/sup 3/H) QNB. Additionally, (/sup 125/I) 4-IQNB exhibits receptor selectivity for the M/sub 1/ receptor since the affinity for the receptor from dog and rat heart is lower than that using dog or rat corpus striatum.
- Research Organization:
- George Washington Univ. Medical Center, Washington, DC
- OSTI ID:
- 6047564
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 34:23; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Characteristics of I-125 4-IQNB and H-3 QNB in vivo and in vitro. [Rats]
Preparation and properties of (R)-(-)-1-azabicyclo(2. 2. 2)oct-3-yl- (R)-(+)-alpha-hydroxy-alpha-(4-( sup 125 I)iodophenyl)-alpha-phenyl acetate and (R)-(-)-1-azabicyclo(2. 2. 2)oct-3-yl-(S)-(-)-alpha-hydroxy-alpha- (4-( sup 125 I)iodophenyl)-alpha-phenyl acetate as potential radiopharmaceuticals
(Development of gamma-emitting, receptor-binding radiotracers for imaging the brain and pancreas): Progress report, March 1, 1987-February 28, 1988
Journal Article
·
Tue Jan 31 23:00:00 EST 1984
· J. Nucl. Med.; (United States)
·
OSTI ID:5176529
Preparation and properties of (R)-(-)-1-azabicyclo(2. 2. 2)oct-3-yl- (R)-(+)-alpha-hydroxy-alpha-(4-( sup 125 I)iodophenyl)-alpha-phenyl acetate and (R)-(-)-1-azabicyclo(2. 2. 2)oct-3-yl-(S)-(-)-alpha-hydroxy-alpha- (4-( sup 125 I)iodophenyl)-alpha-phenyl acetate as potential radiopharmaceuticals
Journal Article
·
Sun Oct 01 00:00:00 EDT 1989
· Journal of Pharmaceutical Sciences; (USA)
·
OSTI ID:7244564
(Development of gamma-emitting, receptor-binding radiotracers for imaging the brain and pancreas): Progress report, March 1, 1987-February 28, 1988
Technical Report
·
Wed Dec 31 23:00:00 EST 1986
·
OSTI ID:5933191
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ACETIC ACID ESTERS
ACETYLCHOLINE
AFFINITY
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
CARBOXYLIC ACID ESTERS
CARDIOVASCULAR SYSTEM
CHEMICAL BONDS
DAYS LIVING RADIOISOTOPES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
HEART
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGANDS
MAMMALS
MUSCLES
NEUROREGULATORS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
QUATERNARY COMPOUNDS
RADIOASSAY
RADIOISOTOPES
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ACETIC ACID ESTERS
ACETYLCHOLINE
AFFINITY
AMINES
AMMONIUM COMPOUNDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
CARBOXYLIC ACID ESTERS
CARDIOVASCULAR SYSTEM
CHEMICAL BONDS
DAYS LIVING RADIOISOTOPES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
HEART
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LIGANDS
MAMMALS
MUSCLES
NEUROREGULATORS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PARASYMPATHOMIMETICS
QUATERNARY COMPOUNDS
RADIOASSAY
RADIOISOTOPES
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES