Clearance of calcium pyrophosphate dihydrate crystals in vivo. II. Studies using triblinic crystals doubly labeled with 45Ca and 85Sr
The clearance rate of isotopically labeled synthetic triclinic calcium pyrophosphate dihydrate (CPPD) crystals injected into rabbit joints was estimated by serial counting. Kinetic analysis using a four compartment model showed that half of the injected dose was cleared from 4 rabbit knee joints in 19.1 +- 0.42 (SEM) days. Profound hypomagnesemia, produced in 2 rabbits with a low magnesium diet, did not affect the rate of crystal clearance detectably. Lavage of joints with solutions known to promote CPPD crystal solubility failed to remove detectable radioactivity. The previous finding of CPPD crystals in synovial phagocytes by electron microscopy, together with the finding of nuclide activity in the synovium and the failure to remove such activity by joint lavage, suggests that endocytosis by synovial cells is an important, effective mechanism controlling the synovial fluid concentration of crystals in patients with CPPD crystal deposition disease.
- Research Organization:
- Medical Coll. of Wisconsin, Milwaukee
- OSTI ID:
- 6041680
- Journal Information:
- Arthritis Rheum.; (United States), Journal Name: Arthritis Rheum.; (United States) Vol. 22:10; ISSN ARHEA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ALKALINE EARTH METALS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BONE JOINTS
CALCIUM 45
CALCIUM COMPOUNDS
CALCIUM ISOTOPES
CLEARANCE
CRYSTALS
DAYS LIVING RADIOISOTOPES
DIET
DISEASES
DISSOLUTION
ELECTRON CAPTURE RADIOISOTOPES
ELECTRON MICROSCOPY
ELEMENTS
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
IN VIVO
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LAVAGE
MAGNESIUM
MAMMALS
MATERIALS
METABOLIC DISEASES
METABOLISM
METALS
MICROSCOPY
NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHAGOCYTES
PHOSPHORUS COMPOUNDS
PYROPHOSPHATES
RABBITS
RADIOISOTOPES
RADIONUCLIDE KINETICS
SKELETON
SOMATIC CELLS
STRONTIUM 85
STRONTIUM ISOTOPES
TRACER TECHNIQUES
VERTEBRATES