Protection against chemical-induced lung injury by inhibition of pulmonary cytochrome P-450
Journal Article
·
· Environmental Health Perspectives; (USA)
- Medical Research Council Laboratories, Carshalton Surrey (England)
Protection afforded by trialkyl phosphorothionates against the lung injury caused by trialkyl phosphorothiolates probably results from the inhibition by the P{double bond}S moiety of the thionates, of one or more pulmonary cytochrome P-450 isozymes. The aromatic hydrocarbons p-xylene and pseudocumene also protect against this injury and inhibit some P-450 isozymes, but by a different mechanism. OOS-Trimethylphosphorothionate and p-xylene were compared as protective agents against the effect of OOS-trimethylphosphorothiolate and two other lung toxins ipomeanol and 1-nitronaphthalene that are known to be activated by cytochrome P-450. The effects of these protective compounds, in vivo, on pulmonary cytochrome P-450 activity were also determined. Both compounds inhibited pentoxyresorufin O-deethylase activity, but not ethoxyresorufin O-deethylase. The phosphorothionate was most effective against lung injury caused by the phosphorothiolates and 1-nitronaphthalene, whereas p-xylene was much more effective against ipomeanol. {beta}-Naphthoflavone, which induces pulmonary ethoxyresorufin O-deethylase activity, did not protect against phosphorothiolate or 1-nitronaphthalene injury, and it was only marginally effective in decreasing the toxicity or ipomeanol.
- OSTI ID:
- 6034653
- Journal Information:
- Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 85; ISSN 0091-6765; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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Effect of carbon monoxide on xenobiotic metabolism in the isolated perfused rabbit lung
Journal Article
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Thu Dec 31 23:00:00 EST 1987
· J. Toxicol. Environ. Health; (United States)
·
OSTI ID:6754349
Effect of carbon monoxide on the cytochrome P-450-mediated activation of 4-ipomeanol by the isolated perfused rabbit lung
Journal Article
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Sat Dec 31 23:00:00 EST 1988
· Journal of Toxicology and Environmental Health; (USA)
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OSTI ID:5014732
Effect of carbon monoxide on xenobiotic metabolism in the isolated perfused rabbit lung
Thesis/Dissertation
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Thu Dec 31 23:00:00 EST 1987
·
OSTI ID:5400398
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHEMICAL ACTIVATION
CYTOCHROME OXIDASE
ENZYMES
EPITHELIUM
FLAVENOIDS
FLAVONES
HAEM DEHYDROGENASES
INHIBITION
INJURIES
ISOENZYMES
LUNGS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CHEMICAL ACTIVATION
CYTOCHROME OXIDASE
ENZYMES
EPITHELIUM
FLAVENOIDS
FLAVONES
HAEM DEHYDROGENASES
INHIBITION
INJURIES
ISOENZYMES
LUNGS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RESPIRATORY SYSTEM
RODENTS
TISSUES
VERTEBRATES