Effects of alismol isolated from Alismatis Rhizoma on calcium-induced contraction in the rabbit thoracic aorta

Journal Article · Mon Oct 12 00:00:00 EDT 1987 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(87)90704-1· OSTI ID:6031016

Matsuda, H; Kobayashi, G; Yamahara, J; Fujimura, H; Kurahashi, K; Fujiwara, M

The authors examined the inhibitory effects of alismol, a sesquiterpenoid isolated from Alismatis Rhizoma, on vascular contractions induced by high concentrations of K/sup +/ and Ca/sup 2 +/, and on /sup 45/Ca/sup 2 +/ retention in normal and in high K/sup +/-containing medium. Alismol affected neither the resting tension nor the /sup 45/Ca/sup 2 +/ retention in normal medium, but it inhibited sustained contraction and increased /sup 45/Ca/sup 2 +/ retention induced by high K/sup +/ concentrations. Alismol did not affect norepinephrine-induced contractions in normal medium, nor phasic contractions in Ca/sup 2 +/-free medium. These results suggested that alismol inhibited mainly Ca/sup 2 +/ influx through a voltage-dependent Ca/sup 2 +/ channel. 19 references, 6 figures.

• Research Organization: Kyoto Pharmaceutical Univ., Japan
• OSTI ID: 6031016
• Journal Information: Life Sci.; (United States), Vol. 41:15
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AORTA
CONTRACTION
CALCIUM COMPOUNDS
MEMBRANE TRANSPORT
DRUGS
BIOLOGICAL EFFECTS
CALCIUM 45
CATIONS
EXPERIMENTAL DATA
INHIBITION
POTASSIUM COMPOUNDS
RABBITS
TRACER TECHNIQUES
ALKALI METAL COMPOUNDS
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CALCIUM ISOTOPES
CARDIOVASCULAR SYSTEM
CHARGED PARTICLES
DATA
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
INFORMATION
INTERMEDIATE MASS NUCLEI
IONS
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
NUMERICAL DATA
ORGANS
RADIOISOTOPES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques