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Effect of dietary chromium on glucose tolerance and serum cholesterol in guinea pigs

Conference · · J. Nutr.; (United States)
OSTI ID:6027094
; ; ;

The effects of feeding three levels of dietary chromium (Cr) to non-pregnant guinea pigs, guinea pigs during pregnancy and lactation and F-1 offspring guinea pigs on weight gain, glucose tolerance, glucose peak time value and serum cholesterol concentration has been investigated. Dietary levels of Cr were: Basal Diet (B) = 0.125 ppm; B supplemented with 0.5 ppm Cr (S/sub 1/ Diet) and B supplemented with 50 ppm Cr (S/sub 2/ Diet). All groups had similar weight gain patterns and daily feed intake levels. Parent generation guinea pigs fed the B diet consumed less than 10 ..mu..g Cr/kg body weight/day while F-1 guinea pigs consumed more than this amount. Mortality rates during pregnancy were greater in guinea pigs fed the B diet than in the Cr supplemented groups suggesting a possible protective effect by Cr. Glucose tolerance, glucose peak time values and serum cholesterol appeared to be more affected by pregnancy and generation of guinea pigs than by the level of dietary Cr. Results suggest that species differences may exist between Cr requirements of guinea pigs and rodents for avoiding glucose intolerance.

Research Organization:
Lincoln Univ., Jefferson City, MO
OSTI ID:
6027094
Journal Information:
J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 106:10; ISSN JONUA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
BLOOD CHEMISTRY
BLOOD SERUM
CARBOHYDRATES
CHOLESTEROL
CHROMIUM
ELEMENTS
GLUCOSE
GUINEA PIGS
HEXOSES
HYDROXY COMPOUNDS
MAMMALS
METABOLISM
METALS
MONOSACCHARIDES
NEONATES
ORGANIC COMPOUNDS
RODENTS
SACCHARIDES
STEROIDS
STEROLS
TOLERANCE
TRANSITION ELEMENTS
VERTEBRATES
WEIGHT