MR image-guided P-31 MR spectroscopy in the evaluation of brain tumor treatment
Magnetic resonance (MR) image-guided phosphorus-31 MR spectra have been obtained from in situ brain tumors. The volumes of interest used for spectroscopy were defined from hydrogen-1 MR images. Direct comparisons were possible between normal and abnormal tissue, since P-31 spectra from different parts of the brain could be measured in a single examination. P-31 MR spectra of the tumors often showed abnormally high concentrations of phosphomonoesters and low concentrations of phosphocreatines. The effects of pharmacotherapy and radiation therapy were studied in three patients; in each of these cases changes were observed in the P-31 spectra of the tumor. The correlation between MR imaging and P-31 MR spectroscopy was essential for the interpretations of these results.
- Research Organization:
- Universite Libre de Bruxelles, Belgium
- OSTI ID:
- 6026557
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 165:1; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMBINED THERAPY
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
NEOPLASMS
NERVOUS SYSTEM
NMR IMAGING
NMR SPECTRA
NONMETALS
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PHOSPHORUS
PHOSPHORUS 31
PHOSPHORUS ISOTOPES
RESONANCE
SPECTRA
STABLE ISOTOPES
THERAPY