Left globus pallidus abnormality in never-medicated patients with schizophrenia
Schizophrenia is a severe psychiatric disorder characterized by onset in young adulthood, the occurrence of hallucinations and delusions, and the development of enduring psychosocial disability. The pathophysiology of this disorder remains unknown. Studies of cerebral blood flow and metabolism designed to identify brain abnormalities in schizophrenia have been limited by inadequate methods of anatomical localization and the possibility of persistent medication effects. The authors have now used positron emission tomography and a validated method of anatomical localization in an attempt to identify abnormalities of regional cerebral blood flow in newly diagnosed never-medicated patients with schizophrenia. An exploratory study of 5 patients and 10 normal control subjects identified abnormally high blood flow in the left globus pallidus of patients with schizophrenia. A replication study of 5 additional patients and 10 additional control subjects confirmed this finding. No other abnormalities were found.
- Research Organization:
- McDonnell Center for Studies in Higher Brain Function, St. Louis, MO
- OSTI ID:
- 6024624
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Further association study on dopamine D2 receptor variant S311C in Schizophrenia and affective disorders
Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioral specificity
Related Subjects
BLOOD FLOW
DYNAMIC FUNCTION STUDIES
CEREBRUM
POSITRON COMPUTED TOMOGRAPHY
MEN
MENTAL DISORDERS
PATHOLOGICAL CHANGES
PATIENTS
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
MALES
MAMMALS
MAN
NERVOUS SYSTEM
ORGANS
PRIMATES
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics