Receptor-dependent mechanisms of glucocorticoid and dioxin-induced cleft palate
Glucocorticoids (triamcinolone) and dioxins (TCDD) are highly specific teratogens in the mouse, in that cleft palate is the major malformation observed. Glucocorticoids and TCDD both readily cross the yolk sac and placenta and appear in the developing secondary palate. Structure-activity relationships for glucocorticoid- and TCDD-induced cleft palate suggest a receptor involvement. Receptors for glucocorticoids and TCDD are present in the palate and their levels in various mouse strains are highly correlated with their sensitivity to cleft palate induction. Receptors for glucocorticoids appear to be more prevalent in the palatal mesenchymal cells whereas those for TCDD are probably located in the palatal epithelial cells. Glucocorticoids exert their teratogenic effect on the palate by inhibiting the growth of the palatal mesenchymal cells whereas TCDD alters the terminal cell differentiation of the media palatal epithelial cells. 71 references.
- Research Organization:
- National Institute of Environmental Health Sciences, Research Triangle Park, NC
- OSTI ID:
- 6023350
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 61
- Country of Publication:
- United States
- Language:
- English
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DIOXIN
STRUCTURE-ACTIVITY RELATIONSHIPS
TERATOGENESIS
GLUCOCORTICOIDS
MICE
CONGENITAL MALFORMATIONS
ANIMAL CELLS
CELL DIFFERENTIATION
EGGS
EPITHELIUM
GROWTH
INHIBITION
ORAL CAVITY
ORGANIC CHLORINE COMPOUNDS
PLACENTA
RECEPTORS
SENSITIVITY
TERATOGENS
ADRENAL HORMONES
ANIMAL TISSUES
ANIMALS
BODY
CORTICOSTEROIDS
DIGESTIVE SYSTEM
FETAL MEMBRANES
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MALFORMATIONS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PREGNANES
PROTEINS
RODENTS
STEROID HORMONES
STEROIDS
TISSUES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)