Receptor-dependent mechanisms of glucocorticoid and dioxin-induced cleft palate
Journal Article
·
· Environ. Health Perspect.; (United States)
Glucocorticoids (triamcinolone) and dioxins (TCDD) are highly specific teratogens in the mouse, in that cleft palate is the major malformation observed. Glucocorticoids and TCDD both readily cross the yolk sac and placenta and appear in the developing secondary palate. Structure-activity relationships for glucocorticoid- and TCDD-induced cleft palate suggest a receptor involvement. Receptors for glucocorticoids and TCDD are present in the palate and their levels in various mouse strains are highly correlated with their sensitivity to cleft palate induction. Receptors for glucocorticoids appear to be more prevalent in the palatal mesenchymal cells whereas those for TCDD are probably located in the palatal epithelial cells. Glucocorticoids exert their teratogenic effect on the palate by inhibiting the growth of the palatal mesenchymal cells whereas TCDD alters the terminal cell differentiation of the media palatal epithelial cells. 71 references.
- Research Organization:
- National Institute of Environmental Health Sciences, Research Triangle Park, NC
- OSTI ID:
- 6023350
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 61; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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Critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: Recent advances toward understanding the mechanism
Journal Article
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Tue May 01 00:00:00 EDT 1990
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OSTI ID:6747838
Cellular alterations and enhanced induction of cleft palate after coadministration of retinoic acid and TCDD
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Thu Jun 15 00:00:00 EDT 1989
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Technical Report
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Sun Dec 31 23:00:00 EST 1989
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OSTI ID:5458577
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CELL DIFFERENTIATION
CONGENITAL MALFORMATIONS
CORTICOSTEROIDS
DIGESTIVE SYSTEM
DIOXIN
EGGS
EPITHELIUM
FETAL MEMBRANES
GLUCOCORTICOIDS
GROWTH
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
INHIBITION
KETONES
MALFORMATIONS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
MICE
ORAL CAVITY
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PLACENTA
PREGNANES
PROTEINS
RECEPTORS
RODENTS
SENSITIVITY
STEROID HORMONES
STEROIDS
STRUCTURE-ACTIVITY RELATIONSHIPS
TERATOGENESIS
TERATOGENS
TISSUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CELL DIFFERENTIATION
CONGENITAL MALFORMATIONS
CORTICOSTEROIDS
DIGESTIVE SYSTEM
DIOXIN
EGGS
EPITHELIUM
FETAL MEMBRANES
GLUCOCORTICOIDS
GROWTH
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
INHIBITION
KETONES
MALFORMATIONS
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
MICE
ORAL CAVITY
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PLACENTA
PREGNANES
PROTEINS
RECEPTORS
RODENTS
SENSITIVITY
STEROID HORMONES
STEROIDS
STRUCTURE-ACTIVITY RELATIONSHIPS
TERATOGENESIS
TERATOGENS
TISSUES
VERTEBRATES