Repair-resistant mutation in Neurospora
Journal Article
·
· Genetics; (United States)
OSTI ID:6019657
Chronic UV treatment produces severalfold fewer mutations in Neurospora conidia than does the same total dose of acute UV. Experiments were designed to determine the conditions required for chronic UV mutagenesis. Measurement of the coincidence frequency for two independent mutations revealed the existence of a subset of cells which are mutable by chronic UV. Analysis of forward mutation at the mtr locus showed that the genetic alterations produced by chronic UV were virtually all point mutants, even though the assay system could detect alterations or deletions extending into neighboring genes. A significant fraction of the mutants produced by acute UV were multigenic deletions. The size of the dose-rate effect (acute UV mutation frequency divided by chronic UV mutation frequency) was compared for several different mutation assay systems. Forward mutations (recessive lethals and mtr) gave values ranging from four to nine. For events which were restricted to specific molecular sites (specific reversions and nonsense suppressor mutations), there was a wider range of dose-rate ratios. This suggests that chronic UV mutation may be restricted to certain molecular sequences or configurations.
- Research Organization:
- Univ. of Washington, Seattle
- OSTI ID:
- 6019657
- Journal Information:
- Genetics; (United States), Journal Name: Genetics; (United States) Vol. 116:2; ISSN GENTA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Genetic control of radiation sensitivity and DNA repair in Neurospora
Rediscovery by Whole Genome Sequencing: Classical Mutations and Genome Polymorphisms in Neurospora crassa
Specificity of mutation by UV light and delayed photoreversal in umuC-defective Escherichia coli K-12: a targeting intermediate at pyrimidine dimers
Conference
·
Tue Dec 31 23:00:00 EST 1974
·
OSTI ID:4144516
Rediscovery by Whole Genome Sequencing: Classical Mutations and Genome Polymorphisms in Neurospora crassa
Journal Article
·
Thu Jun 02 00:00:00 EDT 2011
· G3
·
OSTI ID:1165863
Specificity of mutation by UV light and delayed photoreversal in umuC-defective Escherichia coli K-12: a targeting intermediate at pyrimidine dimers
Journal Article
·
Tue Mar 31 23:00:00 EST 1987
· J. Bacteriol.; (United States)
·
OSTI ID:6612439
Related Subjects
560130* -- Radiation Effects on Microorganisms
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHRONIC EXPOSURE
DNA REPAIR
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
FUNGI
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
MUTAGENESIS
MUTATION FREQUENCY
MUTATIONS
NEUROSPORA
PLANTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
ULTRAVIOLET RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHRONIC EXPOSURE
DNA REPAIR
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
FUNGI
GENES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
MUTAGENESIS
MUTATION FREQUENCY
MUTATIONS
NEUROSPORA
PLANTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RECOVERY
REPAIR
ULTRAVIOLET RADIATION