Artifact formation during smoke trapping: An improved method for determination of N-nitrosamines in cigarette smoke
- R. J. Reynolds Tobacco Co., Winston-Salem, NC (USA)
Studies in our laboratory revealed artifactual formation of N-nitrosamines during trapping of mainstream and sidestream tobacco smoke by the method of Hoffmann and coworkers. Both volatile and tobacco-specific N-nitrosamines were produced. This artifact formation took place on the Cambridge filter, which is part of the collection train used in the previously published procedure. When the filter was treated with ascorbic acid before smoke collection, artifact formation was inhibited. The improved method resulting from these studies was applied to a comparative analysis of N-nitrosamines in smoke from cigarettes that heat, but do not burn, tobacco (the test cigarette) and several reference cigarettes. Concentrations of volatile and tobacco-specific N-nitrosamines in both mainstream and sidestream smoke from the test cigarette were substantially lower than in the reference cigarettes.
- OSTI ID:
- 6016039
- Journal Information:
- Journal of the Association of Official Analytical Chemists; (USA), Journal Name: Journal of the Association of Official Analytical Chemists; (USA) Vol. 73:5; ISSN 0004-5756; ISSN JANCA
- Country of Publication:
- United States
- Language:
- English
Similar Records
The contribution of low tar cigarettes to environmental tobacco smoke
Selenium-mediated reduction in the mutagenicity of cigarette smoke
Related Subjects
540120* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (1990-)
AEROSOLS
AMINES
CHROMATOGRAPHY
COLLOIDS
DISPERSIONS
ECOLOGICAL CONCENTRATION
GAS CHROMATOGRAPHY
MEASURING METHODS
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
REAGENTS
RESIDUES
SEPARATION PROCESSES
SMOKES
SOLS
TOBACCO SMOKES