Scintigraphic detection of carotid atherosclerosis with indium-111-labeled autologous platelets

Journal Article · Thu May 01 00:00:00 EDT 1980 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.61.5.982· OSTI ID:6012158

Davis, H H; Siegel, B A; Sherman, L A; Heaton, W A; Naidich, T P; Joist, J R; Welch, M J

Using autologous platelets labeled with indium-111-oxine, we studied the localization of platelets on arterial lesions by radionuclide scintigraphy in 34 patients with suspected cerebrovascular disease. The imaging results were compared with the findings of contrast angiography in 23 patients, 16 of whom were receiving antiplatelet and/or anticoagulant drugs during the platelet imaging study. Angiography demonstrated atherosclerotic lesions at 33 sites in the extracranial arteries of 16 of these patients. There was accumulation of /sup 111/In-platelets at 20 of these sites (61%) and at three other sites without definite angiographic abnormalities. Lesions with stenoses <50% were slightly more frequent than those with greater stenosis (68% vs 45%). The frequency of true-positive scintigraphic results was slightly higher in patients not treated with antithrombotic agents than in those on such drugs (70% vs 57%). Our results suggest that imaging with /sup 111/In-labeled autologous platelets may be useful for evaluating the pathophysiologic characteristics of atherosclerotic lesions in patients with cerebrovascular disease.

• Research Organization: Washington Univ., St. Louis, MO (United States). School of Medicine
• OSTI ID: 6012158
• Journal Information: Circulation; (United States), Vol. 61:5
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIOSCLEROSIS
DIAGNOSIS
SCINTISCANNING
INDIUM 111
ANTICOAGULANTS
ARTERIES
BLOOD PLATELETS
LABELLING
NUCLEAR MEDICINE
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD VESSELS
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CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEMATOLOGIC AGENTS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
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550601* - Medicine- Unsealed Radionuclides in Diagnostics