Captopril suppresses benign and malignant reactions in irradiated rat skin

Conference · Mon Feb 26 04:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:6007934

Ward, W; Molteni, A; Ts'ao, C; Hinz, J ^[1]

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1. Northwestern Univ., Chicago, IL (United States)

The severity of epilation and moist desquamation, and the incidence of cutaneous tumors were determined in male rats up to 52 weeks after exposure to a range of single doses (0-30 Gy) of gamma rays to the right hemithorax. Half of each radiation dose group consumed control feed, and half consumed feed containing 0.1% (w/w) of the angiotensin converting enzyme inhibitor Captopril (50 mg/kg/day) continuously after irradiation. Rats exposed to 10 Gy exhibited a mild and transient epilation, but no moist desquamation or neoplasms in the radiation port. In animals exposed to 30 Gy, however, epilation began at 2 weeks after irradiation, reached a peak at 7 weeks, then persisted through 52 weeks. Captopril has no effect on the epilation reaction. Two waves of moist desquamation were observed after 30 Gy. The first appeared at 3 weeks after irradiation, reached a peak from 6-10 weeks, then subsided from 12-26 weeks. The second wave of moist desquamation began at 26-28 weeks, and occasionally was accompanied by the appearance of tumors in the radiation port. Captopril reduced the severity of both phases of moist desquamation, and decreased the incidence of tumors. Of the 14 tumors detected in 128 rats exposed to 20 or 30 Gy, all were fibrosarcomas or squamous cell carcinomas, and only 3 occurred in rats receiving Captopril. Multiple tumors (3 cases), tumors induced by 20 Gy (3 cases), and tumors appearing before 26 weeks (1 case) were observed only in rats consuming control diet, not in Captopril-treated rats.

• OSTI ID: 6007934
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 4:3
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOMAS
DISEASES
ELECTROMAGNETIC RADIATION
ENZYME INHIBITORS
FIBROSARCOMAS
GAMMA RADIATION
IONIZING RADIATIONS
MAMMALS
NEOPLASMS
ORGANS
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SARCOMAS
SKIN
VERTEBRATES