Dosimetric estimates for clinical positron emission tomographic scanning after injection of ( sup 18 F)-6-fluorodopamine

Journal Article · Mon Dec 31 23:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6005592

Goldstein, D S; Chang, P C; Smith, C B; Herscovitch, P; Austin, S M; Eisenhofer, G; Kopin, I J ^[1]

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1. National Heart, Lung, and Blood Institute, Bethesda, MD (USA)

Positron emission tomographic (PET) scanning after systemic i.v. injection of fluorine-18-6-fluorodopamine (({sup 18}F)-6F-DA) is a method for visualizing and measuring regional sympathetic nervous system innervation and function. Based on results of preclinical studies of rats and dogs and on previous literature about the fate of injected tracer-labeled catecholamines, dosimetric estimates for clinical studies are presented here. After injection of 1 mCi of ({sup 18}F)-F-DA, the radiation dose would be highest to the wall of the urinary bladder (1.40 rem/mCi), due to accumulation of radioactive metabolites of ({sup 18}F)-F-DA in urine. Radioactivity also would accumulate in bile. Organs receiving the next highest dose would be the kidneys (0.9 rem/mCi) and small intestine (0.2 rem/mCi). The parenchymal radiation dose would be lowest in the brain, since there is an effective blood-brain barrier for circulating catecholamines. Radiation doses to all organs after administration of 1 mCi of ({sup 18}F)-F-DA to humans would be less than 3 rem and, therefore, within current FDA guidelines.

• OSTI ID: 6005592
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 32:1; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560162* -- Radionuclide Effects
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& Toxicology-- Animals
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOGS
DOPAMINE
DOSES
DRUGS
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
METABOLISM
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
POSITRON COMPUTED TOMOGRAPHY
RADIATION DOSES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RODENTS
SYMPATHOMIMETICS
TISSUE DISTRIBUTION
TOMOGRAPHY
VERTEBRATES