Effects of fasting and/or oxidizing and reducing agents on absorption of neptunium from the gastrointestinal tract of mice and adult or neonatal rats

Journal Article · Fri Nov 30 23:00:00 EST 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576415· OSTI ID:6004142

Sullivan, M F; Ruemmler, P S; Ryan, J L

Neptunium-237(V) nitrate was administered by gavage to groups of fed or fasted adult and 5-day-old rats. Some groups also received the oxidants quinhydrone or ferric iron and others received the reducing agent ferrous iron. Adult mice received ferric or ferrous iron and /sup 235/Np. When the adult rats were killed at 7 days after gavage, measurements showed that, compared with rats that were fed, a 24-hr fast caused a fivefold increase in /sup 237/Np absorption and retention. Both quinhydrone and ferric iron caused an even greater increase in absorption in both fed and fasted rats. Ferrous iron, on the other hand, decreased absorption in fasted rats to values lower than those obtained in fed rats. Similar results were obtained in mice treated with /sup 235/Np and either ferric or ferrous iron. The effects of ferric and ferrous iron on neptunium absorption by neonatal rats were similar to their effects on adult animals but of lesser magnitude. These results are consistent with the hypothesis that Np(V), when given in small mass quantities to fed animals, is reduced in the gastrointestinal tract to Np(IV), which is less well absorbed than Np(V).

• Research Organization: Pacific Northwest Lab., Richland, WA
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6004142
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 100:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ADULTS
AGE GROUPS
ALPHA DECAY RADIOISOTOPES
ANIMALS
AROMATICS
BENZOQUINONES
BETA DECAY RADIOISOTOPES
CATIONS
CHARGED PARTICLES
DATA
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
FASTING
GASTROINTESTINAL TRACT
HEAVY NUCLEI
INFORMATION
INTESTINAL ABSORPTION
IONS
IRON COMPOUNDS
ISOTOPES
MAMMALS
MICE
NEONATES
NEPTUNIUM 235
NEPTUNIUM 237
NEPTUNIUM COMPOUNDS
NEPTUNIUM ISOTOPES
NEPTUNIUM NITRATES
NITRATES
NITROGEN COMPOUNDS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXYGEN COMPOUNDS
QUINHYDRONE
QUINONES
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
TRANSITION ELEMENT COMPOUNDS
TRANSURANIUM COMPOUNDS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES