Different patterns of developmental toxicity in the rat following prenatal administration of structurally diverse chemicals

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530567· OSTI ID:6004025

Simmons, D L; Valentine, D M; Bradshaw, W S

Differences in the profiles of developmental toxicity for four structurally diverse chemical compounds have been defined following prenatal exposure in the rat. Diethylstilbestrol (DES), 3,4,3',4'-tetrachlorobiphenyl (4CB), zeranol, and cadmium were administered by gavage to Sprague-Dawley rats daily from d 6 through d 18 of gestation. Dams were sacrificed at four prenatal endpoints and the numbers of live and dead fetuses and resorbed embryos were counted. Additional dams were allowed to bring their litters to term, and their offspring were monitored until they reached adulthood. DES induced prenatal death primarily in early embryonic life, and also during parturition. 4CB increased mortality from late in gestation up to 24 h after birth, and altered the sex ratio of survivors by selectively acting against males in utero. Exposure to zeranol resulted in embryolethality only. Cadmium was not lethal to the conceptus at any dose below the dose that caused maternal mortality. Only 4CB had an obvious teratogenic effect, causing intestinal hemorrhage. All compounds produced transient perinatal decreases in the weight of the offspring. 30 references, 6 tables.

• Research Organization: Brigham Young Univ., Provo, UT
• OSTI ID: 6004025
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 14:2-3; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BODY
CADMIUM
CHLORINATED AROMATIC HYDROCARBONS
COMPARATIVE EVALUATIONS
DATA
DIGESTIVE SYSTEM
ELEMENTS
EXPERIMENTAL DATA
FETUSES
GASTROINTESTINAL TRACT
HALOGENATED AROMATIC HYDROCARBONS
HEMORRHAGE
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INFORMATION
INTESTINES
MAMMALS
METALS
MORTALITY
NUMERICAL DATA
ORAL ADMINISTRATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PHENOLS
POLYPHENOLS
PREGNANCY
PRENATAL EXPOSURE
RATS
RODENTS
SEX DEPENDENCE
STILBESTROL
SYMPTOMS
TERATOGENESIS
TOXICITY
VERTEBRATES
WEIGHT