Intraoperative and external beam irradiation with or without resection: Mayo pilot experience

Journal Article · Mon Oct 01 04:00:00 EDT 1984 · Mayo Clin., Proc.; (United States)

DOI:https://doi.org/10.1016/S0025-6196(12)62058-8· OSTI ID:5999699

Gunderson, L L; Martin, Jr, J K; Earle, J D; Byer, D E; Voss, M; Fieck, J M; Kvols, L K; Rorie, D K; Martinez, A; Nagorney, D M

At our institution, intraoperative radiation therapy (IORT) with an electron beam has been administered as a single boost dose of 1,000 to 2,000 cGy (rad) in combination with 4,500 to 5,000 cGy (rad) of fractionated external beam irradiation. From April 1981 to July 1983, 50 patients received such treatment, and results are analyzed in detail in this article. All patients had locally advanced disease (initially unresectable for cure, residual after resection, or recurrent), and the main disease sites were gastrointestinal (pancreatic, colorectal, and biliary tumors) and soft tissue (sarcomas). Disease-free survival to date has been excellent in our colorectal and biliary subsets of patients. Although local progression has not been a major problem in patients with unresectable pancreatic lesions, failures in the liver and peritoneal cavity have been excessive, and treatment strategies have been altered in an attempt to decrease the frequency of such failures. Although both short-term and long-term morbidity are acceptable, pilot trials with use of radiation-dose modifiers are planned to determine whether the therapeutic ratio of local control to associated complications can be improved even further.

• OSTI ID: 5999699
• Journal Information: Mayo Clin., Proc.; (United States), Journal Name: Mayo Clin., Proc.; (United States) Vol. 59:10; ISSN MACPA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BEAMS
BODY
DIGESTIVE SYSTEM
DISEASES
DOSES
ELECTRON BEAMS
GASTROINTESTINAL TRACT
GLANDS
LEPTON BEAMS
LIVER
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PARTICLE BEAMS
PATIENTS
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
SURVIVAL TIME
THERAPY