Functional corticotropin-releasing factor receptors in neonatal rat spinal cord

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Peptides (Fayetteville, N.Y.); (United States)

DOI:https://doi.org/10.1016/0196-9781(88)90198-2· OSTI ID:5998548

Bell, J A; de Souza, E B

The present study localized corticotropin-releasing factor (CRF) receptors and studied the action of CRF in the neonatal rat spinal cord preparation. Lumbar CRF receptors were present in highest concentrations in laminae I and II with progressively lower concentrations in lamina IX and intermediate and central zones respectively. CRF directly and indirectly depolarized lumbar motoneurons in a concentration-related manner and the putative receptor antagonist, alpha helical oCRF(9-41), partially blocked the depolarizing response to CRF. The electrophysiological responses to CRF and the distribution of receptors within the spinal cord suggest that CRF may play a physiological role in regulating spinal cord reflex function.

• Research Organization: National Institute on Drug Abuse, Baltimore, MD (USA)
• OSTI ID: 5998548
• Journal Information: Peptides (Fayetteville, N.Y.); (United States), Journal Name: Peptides (Fayetteville, N.Y.); (United States) Vol. 9:6; ISSN PPTDD
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL LOCALIZATION
CENTRAL NERVOUS SYSTEM
ELECTROPHYSIOLOGY
IODINE ISOTOPES
ISOTOPES
MAMMALS
MEMBRANE PROTEINS
NEONATES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
PEPTIDES
PHYSIOLOGY
PROTEINS
RATS
RECEPTORS
RODENTS
SPINAL CORD
VERTEBRATES