Structure activity relationships of selected naphthalene derivatives

Journal Article · Fri Dec 31 23:00:00 EST 1982 · Ecotoxicol. Environ. Saf.; (United States)

DOI:https://doi.org/10.1016/0147-6513(83)90065-9· OSTI ID:5997318

Schultz, T W; Dumont, J N; Sankey, F D; Schmoyer, Jr, R L

Twenty-two derivatives of naphthalene were assayed under an acute static regime with biological activity being monitored as population growth of Tetrahymena pyriformis. Activity varied over one log unit. Substituent constant structure-activity analyses revealed the model, log BR = 0.282Ha + 0.352..pi.. + 0.692F + 0.334/sup 1/X/sub sub//sup v/ - 0.326R + 0.027, to be best and to account for 85% of the variation in log BR (BR, biological response; Ha, hydrogen acceptance; ..pi.., hydrophobic substituent constant; F, polar electronic substituent constant, /sup 1/X/sub sub//sup v/, substituent molar connectivity index; R, resonance electronic substituent constant). The Ha and ..pi.. parameters are the most important, accounting for 71% of the log BR variability. 21 references, 1 figure, 7 tables.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5997318
• Journal Information: Ecotoxicol. Environ. Saf.; (United States), Journal Name: Ecotoxicol. Environ. Saf.; (United States) Vol. 7; ISSN EESAD
• Country of Publication: United States
• Language: English

Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
CILIATA
CONDENSED AROMATICS
DATA
EXPERIMENTAL DATA
GROWTH
HYDROCARBONS
INFORMATION
INVERTEBRATES
MATHEMATICAL MODELS
MICROORGANISMS
MUTAGEN SCREENING
NAPHTHALENE
NUMERICAL DATA
ORGANIC COMPOUNDS
PROTOZOA
SCREENING
STRUCTURE-ACTIVITY RELATIONSHIPS
TETRAHYMENA