Human. beta. interferon gene localization and expression in somatic cell hybrids
Journal Article
·
· Mol. Cell. Biol.; (United States)
The human fibroblast interferon gene ..beta../sub 1/ was mapped to human chromosome 9. Sequence homology with a ..beta../sub 1/ cDNA clone was detected in both genomic DNA and induced mRNA of human/mouse or human/hamster somatic cell hybrids containing human chromosome 9, but not in lines lacking this chromosome or thos retaining a complex translocation involving chromosomes 9 and 11. Interferon mRNA that did not share sequence homology with the ..beta../sub 1/ cDNA clone was detected in lines containing human chromosomes 2 and 5 but lacking chromosome 9, suggesting the presence of other unlinked interferon sequences in the human genome.
- Research Organization:
- Oncology Center, The Johns Hopkins Univ. School of Medicine, Baltimore, MD 21205
- OSTI ID:
- 5996457
- Journal Information:
- Mol. Cell. Biol.; (United States), Journal Name: Mol. Cell. Biol.; (United States) Vol. 2:5; ISSN MCEBD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOCHEMICAL REACTION KINETICS
CHROMOSOMES
CLASSIFICATION
CONNECTIVE TISSUE CELLS
DNA SEQUENCING
FIBROBLASTS
GENES
GENETIC MAPPING
GROWTH FACTORS
HAMSTERS
HYBRIDIZATION
INTERFERON
KINETICS
LYMPHOKINES
MAMMALS
MAN
MAPPING
MESSENGER-RNA
MITOGENS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHENOTYPE
PRIMATES
PROTEINS
RATS
REACTION KINETICS
RNA
RODENTS
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOCHEMICAL REACTION KINETICS
CHROMOSOMES
CLASSIFICATION
CONNECTIVE TISSUE CELLS
DNA SEQUENCING
FIBROBLASTS
GENES
GENETIC MAPPING
GROWTH FACTORS
HAMSTERS
HYBRIDIZATION
INTERFERON
KINETICS
LYMPHOKINES
MAMMALS
MAN
MAPPING
MESSENGER-RNA
MITOGENS
MOLECULAR BIOLOGY
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PHENOTYPE
PRIMATES
PROTEINS
RATS
REACTION KINETICS
RNA
RODENTS
SOMATIC CELLS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES