Medulloblastoma. The identification of prognostic subgroups and implications for multimodality management

Journal Article · Sat Jan 15 04:00:00 EST 1983 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19830115)51:2<312::AID-CNCR2820510225>3.0.CO;2-Y· OSTI ID:5995267

Kopelson, G; Linggood, R M; Kleinman, G M

For 43 medulloblatoma patients who had five-and ten-year actuarial survival rates of 56%, prognostic factors of statistical significance included: T-stage, M-stage and histopathologic tumor score. Posterior fossa local control rates were also function of T-stage and TS. Combining TS with T-stage, patients fell into three prognostic and local control groups, which may have different future management implications: Small (T1,2) tumors of favorable (TS less than or equal to 5) histology had a 92% ten-year actuarial survival rate with 100% (8/8) local control; no change from current management is suggested. For the intermediate prognosis group, increasing the irradiation dose alone may improve survival because these tumors exhibited an irradiation dose-response relationship. However, it is the poor prognosis group which might be suitable for future adjuvant chemotherapy or radiosensitizer trials since there is no evidence that higher irradiation doses improve local control. This article identifies prognostic subgroups based on histologic type and TM staging in medulloblastoma patients which potentially may be utilized to improve therapeutic results, and confirms the value of staging patients with central nervous system malignancies.

• Research Organization: Department of Radiation Medicine, Massachusetts General Hospital, Boston
• OSTI ID: 5995267
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 51:2; ISSN CANCA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMOTHERAPY
CLASSIFICATION
COMPARATIVE EVALUATIONS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
HISTOLOGY
MATHEMATICS
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RISK ASSESSMENT
SPINAL CORD
STATISTICS
SURVIVAL CURVES
THERAPY