C-11-labeled glucose and its utilization in positron-emission tomography
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5994798
Carbon-11-labeled glucose was prepared photosynthetically using the green alga Scenedesmus obtusiusculus Chod. The carbohydrates were extracted from the cells with dilute HCI and the glucose was isolated and purified using high-performance liquid chromatography. The manipulations in the hot cell are described. Analysis of the material (gas liquid chromatography and HPLC) showed that the glucose obtained was radiochemically pure. The total incorporation of the 11CO2 added to the algae was 60-80%. The radiochemical yield of pure carrier-added glucose was approximately 25%, at 40 min after E.O.B. including the HPLC purification and sterile filtration. The C-11 glucose uptake in rat brain was compared with that of commercial D(U-/sup 14/C)glucose, and preliminary PET studies with D-(/sup 11/C)glucose in a patient with a brain infarct are presented.
- Research Organization:
- Karolinska Hospital, University of Stockholm, Sweden
- OSTI ID:
- 5994798
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:4; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Radiocarbon labeled fully deuterated glucose: Preparation, chromatography and preliminary distribution studies
Synthesis of carbon-11 labeled dexetimide and levetimide for studying muscarinic acetylcholine receptors
Positron emission tomography with ((/sup 11/C)methyl)-L-methionine, (/sup 11/C)D-glucose, and (/sup 68/Ga)EDTA in supratentorial tumors
Conference
·
Wed May 01 00:00:00 EDT 1985
· J. Nucl. Med.; (United States)
·
OSTI ID:7033477
Synthesis of carbon-11 labeled dexetimide and levetimide for studying muscarinic acetylcholine receptors
Conference
·
Wed May 01 00:00:00 EDT 1985
· J. Nucl. Med.; (United States)
·
OSTI ID:6852451
Positron emission tomography with ((/sup 11/C)methyl)-L-methionine, (/sup 11/C)D-glucose, and (/sup 68/Ga)EDTA in supratentorial tumors
Journal Article
·
Mon Jul 01 00:00:00 EDT 1985
· J. Comput. Assist. Tomogr.; (United States)
·
OSTI ID:5126736
Related Subjects
09 BIOMASS FUELS
140504 -- Solar Energy Conversion-- Biomass Production & Conversion-- (-1989)
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ALGAE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOSYNTHESIS
BODY
BRAIN
CARBOHYDRATES
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
GLUCOSE
HEXOSES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PLANTS
POSITRON COMPUTED TOMOGRAPHY
PURIFICATION
RADIOISOTOPES
RATS
RODENTS
SACCHARIDES
SYNTHESIS
TOMOGRAPHY
UPTAKE
VERTEBRATES
140504 -- Solar Energy Conversion-- Biomass Production & Conversion-- (-1989)
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ALGAE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOSYNTHESIS
BODY
BRAIN
CARBOHYDRATES
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
GLUCOSE
HEXOSES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PLANTS
POSITRON COMPUTED TOMOGRAPHY
PURIFICATION
RADIOISOTOPES
RATS
RODENTS
SACCHARIDES
SYNTHESIS
TOMOGRAPHY
UPTAKE
VERTEBRATES