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Impact of low level cadmium feeding on blood chemicals in male, Sprague-Dawley rats

Conference · · Trace Subst. Environ. Health; (United States)
OSTI ID:5994240
; ; ; ;

The effect of low level dietary cadmium on hemoglobin, hematocrit and serum amylase, zinc, copper and ceruloplasmin in male, Sprague-Dawley rats has been investigated. The rats were fed semipurified diet and housed in individual stainless steel cages in an environmentally controlled room. The intake of copper, zinc and cadmium was controlled through supplementation of drinking water with zinc (2.5, 5 or 10 ppM Zn), copper (0.25, 0.5 or 1 ppM Cu) and cadmium (0 or 17.2 ppM Cd). The serum zinc level varies directly with the concentration of zinc in the dietary regimen. Cadmium ingestion caused a moderate depression of serum zinc. Serum copper and ceruloplasmin are both significantly depressed by ingestion of 17.2 ..mu..g cadmium per ml of drinking water. The principal action of cadmium on serum copper appears to be a depression of the ceruloplasmin bound copper component. No significant differences in the activity of serum amylase or in hemoglobin and hematocrit were observed between the cadmium and noncadmium fed rat groups. Comparison of these results with data for female rats reveals that cadmium feeding has a similar effect on serum, copper and ceruloplasmin levels in male and female rats. 18 references, 5 figures.

Research Organization:
Univ. of Cincinnati, OH
OSTI ID:
5994240
Report Number(s):
CONF-730613-
Journal Information:
Trace Subst. Environ. Health; (United States), Journal Name: Trace Subst. Environ. Health; (United States) Vol. 7; ISSN PUMTA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CADMIUM
CHEMICAL COMPOSITION
CHRONIC EXPOSURE
COMPARATIVE EVALUATIONS
CORRELATIONS
ELEMENTS
MAMMALS
MATERIALS
METALS
RATS
RODENTS
VERTEBRATES