Predictive model of early mortality following acute inhalation of PuO/sub 2/ aerosols. [Extrapolation of beagle data to man]
Since data on the pulmonary toxicity of plutonium in people are not available, estimates must be based upon available experimental animal data. For this purpose, inhalation studies with beagle dogs exposed to aerosols of /sup 238/PuO/sub 2/ and /sup 239/PuO/sub 2/ were analyzed and a simple model has been proposed to describe apparent dose-response relationships. It was found that for each aerosol and radionuclide form, the cumulative absorbed lung dose that leads to death from lung damage up to 1000 days could be assumed to have a log-normal distribution of values that was independent of time to death. The data was satisfactorily fit to a model in which the time of death postexposure is given by: t = (K/D), with the time to death, the cumulative dose to lung tissue (the killing dose), and anti D the average dose rate to lung tissue from time of exposure to death. The ratios of median K values, normalized to the value for /sup 90/Sr--Y FAP, indicate a relative biological effectiveness (RBE) of 14 for /sup 239/PuO/sub 2/ particles and 5 for /sup 238/PuO/sub 2/ particles. This demonstrates an effect of particle specific activity on relative biological effectiveness for early mortality, since an increase in specific activity of particles leads to a lower apparent RBE.
- Research Organization:
- Univ. of California, Davis
- OSTI ID:
- 5993033
- Journal Information:
- Radiat. Res.; (United States), Vol. 78:2
- Country of Publication:
- United States
- Language:
- English
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RADIOINDUCTION
FIBROSIS
LUNGS
EARLY RADIATION EFFECTS
MORTALITY
DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
PLUTONIUM 238
RBE
PLUTONIUM 239
PLUTONIUM DIOXIDE
PNEUMONITIS
ACUTE EXPOSURE
BEAGLES
CERIUM 144
COMPARATIVE EVALUATIONS
EXPERIMENTAL DATA
EXPOSURE CHAMBERS
GRAPHS
INHALATION
ISOLATED VALUES
MAN
RADIOACTIVE AEROSOLS
STRONTIUM 90
THEORETICAL DATA
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AEROSOLS
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CERIUM ISOTOPES
CHALCOGENIDES
COLLOIDS
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DISEASES
DISPERSIONS
DOGS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
HEAVY NUCLEI
INFORMATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NUCLEI
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
PRIMATES
RADIATION EFFECTS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RESPIRATORY SYSTEM
SOLS
STRONTIUM ISOTOPES
SYMPTOMS
TRANSURANIUM COMPOUNDS
VERTEBRATES
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