Adverse pregnancy outcomes in relation to water contamination, Santa Clara County, California, 1980-1981
An epidemiologic study was conducted to investigate a suspected cluster of adverse outcomes of pregnancies conceived in 1980-1981 among women who resided in a census tract in Santa Clara County, California that was thought to be exposed to drinking water from a well contaminated by an organic solvent, trichloroethane. A comparison census tract that received water from a different source was selected on the basis of demographic comparability. The cluster was confirmed; the odds ratio for spontaneous abortion was 2.3 (95% confidence interval (Cl) 1.3-4.2) after adjustment by multiple logistic regression for maternal risk factors, including maternal age, alcohol consumption, smoking, and prior fetal loss. The relative risk for congenital malformations was 3.1 (95% Cl 1.1-10.4). Because of the lack of precise information on the timing and extent of contamination, the pattern of spontaneous abortion rates throughout the study period cannot be used to either support or refute a causal inference.
- Research Organization:
- California Department of Health Services, Berkeley (USA)
- OSTI ID:
- 5992005
- Journal Information:
- Am. J. Epidemiol.; (United States), Vol. 129:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pregnancy outcomes in women potentially exposed to solvent-contaminated drinking water in San Jose, California
The safety of pranlukast and montelukast during the first trimester of pregnancy: A prospective, two‐centered cohort study in Japan
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CALIFORNIA
WATER POLLUTION
CHLORINATED ALIPHATIC HYDROCARBONS
TOXICITY
DRINKING WATER
CONTAMINATION
ABORTION
ENVIRONMENTAL EXPOSURE
EPIDEMIOLOGY
MAN
ORGANIC SOLVENTS
PREGNANCY
RISK ASSESSMENT
WEIGHT
ANIMALS
FEDERAL REGION IX
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROGEN COMPOUNDS
MAMMALS
NORTH AMERICA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXYGEN COMPOUNDS
POLLUTION
PRIMATES
SOLVENTS
USA
VERTEBRATES
WATER
520200* - Environment
Aquatic- Chemicals Monitoring & Transport- (-1989)
560300 - Chemicals Metabolism & Toxicology