Visual cell profiles for quantitation of premalignant cells in sputum: a preliminary report
Visual cell profiles were used to analyze the distribution of atypical bronchial cells in sputum specimens from cigarette-smoking volunteers, cigarette-smoking asbestos workers and cigarette-smoking uranium miners. The preliminary results of these sputum visual cell profile studies have demonstrated distinctive distributions of bronchial cell atypias in progressive patterns of squamous metaplasia, mild, moderate and severe atypias and carcinoma, similar to those the authors have previously reported using cell image analysis techniques to determine an atypia status index (ASI). The information gained from this study will be helpful in further validating this ASI and subsequently achieving the ultimate goal of employing cell image analysis for the rapid and precise identification of premalignant atypias in sputum.
- Research Organization:
- Department of Pathology, Baylor College of Medicine, Houston, Texas
- OSTI ID:
- 5990642
- Journal Information:
- Acta Cytol.; (United States), Vol. 26:6
- Country of Publication:
- United States
- Language:
- English
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DIAGNOSTIC TECHNIQUES
RESPIRATORY SYSTEM DISEASES
ASBESTOS
BRONCHI
HEALTH HAZARDS
MINERS
PERSONNEL
TOBACCO SMOKES
URANIUM MINES
AEROSOLS
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BIOLOGY
COLLOIDS
DISEASES
DISPERSIONS
HAZARDS
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NEOPLASMS
RESIDUES
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SOLS
UNDERGROUND FACILITIES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)