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Reactivity of rat abdominal aorta to U46619 following whole-body gamma irradiation

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3577351· OSTI ID:5986485
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Rats exposed to 20 Gy whole-body irradiation demonstrated a depressed aortic responsiveness to the thromboxane mimic, U46619, 48 h postirradiation. The mechanism for this observed response was investigated. Shielding the abdominal aorta attenuated this altered vascular reactivity. Since this suggests that radiation exposure induces local changes in the aorta, vascular smooth muscle function was assessed with cumulative concentrations of KCl. Radiation-induced smooth muscle damage was insufficient to account for the decreased reactivity to U46619. Next, calcium availability for vascular smooth muscle function was evaluated and found not to be responsible for the radiation-induced depression in aortic responsiveness. Finally, the role that cyclooxygenase products play in the depressed contractile response was investigated. Indomethacin treatment prior to and for 48 h after irradiation attenuated the altered vascular reactivity to U46619. These data suggest that a radiation-induced increase in cyclooxygenase products may play a role in the decreased aortic reactivity to the thromboxane mimic.

Research Organization:
Georgetown Univ. Medical Center, Washington, DC (USA)
OSTI ID:
5986485
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 117:3; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
ANIMALS
AORTA
ARTERIES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
ELECTROMAGNETIC RADIATION
ENZYMES
EXTERNAL IRRADIATION
FUNCTIONS
GAMMA RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MUSCLES
ORGANS
OXIDOREDUCTASES
OXYGENASES
PROSTAGLANDINS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
VERTEBRATES
WHOLE-BODY IRRADIATION