External irradiation and one radium application for carcinoma of the cervix. [Both minor and major complications occurred 6 to 14 months after therapy]

Journal Article · Mon Jan 01 04:00:00 EST 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(79)90035-X· OSTI ID:5985614

Tak, W K; Munzenrider, J E; Mitchell, Jr, G W

Between August 1968 and May 1976 at the Tufts--New England Medicl Center, 264 patients with carcinoma of the cervix on intact uteri were treated with external irradiation followed by one radium application. In a majority of patients, external irradiation was given with /sup 60/Co when AP diameter was less than 17 cm, and with a 46 MeV Brown--Boveri Betatron when AP diameter was greater than 17 cm. A whole pelvic dose of 4000 rad was given for tumors smaller than 5 cm in size and 4500 rad for those larger than 5 cm. A dose was then given to the pelvic wall using 4 cm or 5 cm midline blocks. In Stage I disease, tumors of less than 2 cm received no pelvic wall irradiation and tumors greater than 2 cm and Stage IIA patients received 1000 rad to both pelvic walls. In Stage IIB and IIIA disease, a dose of 1000 rad was given to the uninvolved pelvic wall and 1500 rad to the involved site. In Stage IIIB disease, after giving 1500 rad to the involved parametria, an additional 500 rad was given with a reduced field to the area of gross tumor in the parametrium. All patients had one radium application for 72 hr 7 to 14 days after completion of all external irradiation. There were no pelvic failures in Stage I patients, 8/56 in Stage IIA, 10/70 in Stage IIB, and 71/52 in Stage III. The 5 year no evidence of disease (NED) actuarial survival was 100% in early Stage IB (less than 1 cm), 90% in Stage IB (greater than 1 cm), 79% in Stage IIA, 58% in Stage IIB, 42% in Stage III, and 23% in Stage IV. There was no difference in survival or complications between patients who had tandem and colpostats and those had protruding tandem.

• Research Organization: Tufts-New England Medical Center, Boston, MA
• OSTI ID: 5985614
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:1; ISSN IOBPD
• Country of Publication: United States
• Language: English

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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
COBALT 60
COBALT ISOTOPES
DATA
DATA COMPILATION
DATA FORMS
DELAYED RADIATION EFFECTS
DIARRHEA
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRONS
ELEMENTARY PARTICLES
ELEMENTS
ENERGY RANGE
EXTERNAL IRRADIATION
FEMALE GENITALS
FEMALES
FERMIONS
FISTULAE
GAMMA RADIATION
GASTROINTESTINAL TRACT
IMPLANTS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LARGE INTESTINE
LEPTONS
LOCAL IRRADIATION
MALFORMATIONS
MAMMALS
MAN
MEDICINE
METALS
MEV RANGE
MEV RANGE 10-100
MINUTES LIVING RADIOISOTOPES
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PATIENTS
PELVIS
PRIMATES
PROCTITIS
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RADIUM
RECTUM
SIDE EFFECTS
SMALL INTESTINE
SYMPTOMS
THERAPY
URETERS
URINARY TRACT
UTERUS
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WOMEN
YEARS LIVING RADIOISOTOPES