In vitro cytotoxicity and genotoxicity of dibutyltin dichloride and dibutylgermanium dichloride

Journal Article · Fri Jan 01 04:00:00 UTC 1982 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(82)90245-9· OSTI ID:5984122

Li, A P; Dahl, A R; Hill, J O

The cytotoxicity and genotoxicity of dibutyltin dichloride (DBTC) and dibutylgermanium dichloride (DBGC) were studied with in vitro tests. DBTC was approximately 1000-fold higher in cytotoxicity and genotoxicity than DBGC. Both compounds decreased the antibody production by lymphocytes in vitro at noncytotoxic doses, which may explain the immunosuppressive effect of the compounds in vivo. Both compounds induced mutation in Chinese hamster ovary cells, therefore suggesting that they are potentially carcinogenic.

• Research Organization: Lovelace Inhalation Toxicology Research Inst., Albuquerque, NM
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 5984122
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 64; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
BIOASSAY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOGENESIS
CONNECTIVE TISSUE CELLS
DATA
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
GERMANIUM COMPOUNDS
HAMSTERS
IMMUNOSUPPRESSION
INFORMATION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MUTAGENESIS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
PATHOGENESIS
RATS
RODENTS
SOMATIC CELLS
SURVIVAL CURVES
TIN COMPOUNDS
TOXICITY
VERTEBRATES