Effect of irradiation on bone remodelling and the structural integrity of the vertebral column. Doctoral thesis

Technical Report · Mon Jan 01 04:00:00 EST 1990

OSTI ID:5979809

Swenson, K N

The effects of therapeutic levels of radiation on the axial properties of the primate vertebral column were studied. Seven male rhesus monkeys (Macaca mulatta) were irradiated with a single does of 1300 cGy to the specific lumbar vertebrae of L2, L3, and L4. Three additional animals served as controls. Radiographs were taken before the radiation treatment and just prior to sacrifice to determine density changes in the bone. The animal subjects were sacrificed 105 days following the radiation exposure. Biomechanical testing was completed on lumbar levels 2 and 3 to identify changes in strength characteristics following radiation treatment. Histomorphometric analysis of lumbar vertebrae level 4 was completed to identify volume and surface density changes as well as cellular changes. Tetracycline, dicarbomethylaminomethyl fluorescein (DCAF), and xylenol orange were used as bone labeling agents to aid in the histomorphometry and to obtain dynamic parameter changes.

• Research Organization: Air Force Inst. of Tech., Wright-Patterson AFB, OH (USA)
• OSTI ID: 5979809
• Report Number(s): AD-A-227974/3/XAB; AFIT/CI/CIA--90-027D
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DENSITY
DOSES
MAMMALS
MONKEYS
ORGANS
PHYSICAL PROPERTIES
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
SKELETON
VERTEBRAE
VERTEBRATES