Prognostic implications of exercise Thallium-201 scintigraphy in men with non-diagnostic exercise electrocardiograms

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5974382

Iskandrian, A S; Hakki, A H; Kane, S

Previous studies show that exercise (EX) thallium-201 scintigraphy is useful in ascertaining the diagnosis of coronary artery disease (CAD) in patients (pts) with non-diagnostic EX ECGs. This study examines the prognostic value of EX thallium-201 imaging in 196 men with suspected or known CAD who had non-diagnostic EX ECGs (because of submaximal stress or rest ECG abnormalities. Univariate and multivariate survival analysis (Cox-model) revealed that the number of perfusion defects (X/sup 2/ = 5.8, p = 0.02) to be the only significant factor that predicted future cardiac events. Of importance, the clinical presentation, previous MI, QMI, EX duration, and EX heart rate and double product were not predictors of future cardiac events, and did not add independent information to that provided by the number of perfusion defects. Actuarial life table analysis showed that men with greater than or equal to 3 perfusion defects had worse prognosis than those with <3 defects or no defects (Mantel-Cox, p = 0.009). Thus, Ex thallium imaging is useful in risk stratification in men with non-diagnostic EX ECGs.

• Research Organization: Cardiovascular Institute, Hahnemann Univ. Hospital, Philadelphia, PA
• OSTI ID: 5974382
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIAGRAMS
DISEASES
ELECTROCARDIOGRAMS
ELECTRON CAPTURE RADIOISOTOPES
EXERCISE
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MORTALITY
MYOCARDIAL INFARCTION
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RISK ASSESSMENT
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SURVIVAL TIME
THALLIUM 201
THALLIUM ISOTOPES
USES