Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
; ; ; ;
Glutathione is not effectively transported into human lymphoid cells, normal human skin fibroblasts, and fibroblasts from patients with genetic deficiencies of ..gamma..-glutamylcysteine synthetase or glutathione synthetase. On the other hand, the monoethyl ester of glutathione, in which the carboxyl group of the glycine residue is esterified, is readily transported into these cells and is hydrolyzed intracellularly. This leads to greatly increased cellular levels of glutathione, which often exceed those found normally. Glutathione ester was found to protect human lymphoid cells of the CEM line against the lethal effects of irradiation. Under the conditions employed, complete protection was found when the ester was added prior to irradiation. Addition of the ester after irradiation was partially effective, suggesting that GSH may also function in repair processes. 20 references, 3 figures, 1 table.
Research Organization:
Cornell Univ. Medical Coll., New York, NY
OSTI ID:
5973447
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 81:15; ISSN PNASA
Country of Publication:
United States
Language:
English

Similar Records

Modulation of endothelial GSH concentrations: effect of exogenous GSH and GSH monoethyl ester
Journal Article · Tue Feb 28 23:00:00 EST 1989 · J. Appl. Physiol.; (United States) · OSTI ID:5900750
Glutathione, a first line of defense against cadmium toxicity
Journal Article · Tue Sep 01 00:00:00 EDT 1987 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) · OSTI ID:6017125
Survival curves of irradiated glutathione-deficient human fibroblasts: indication of a reduced enhancement of radiosensitivity by oxygen and misonidazole
Journal Article · Sun Feb 28 23:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:6715136

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CONNECTIVE TISSUE CELLS
DRUGS
ESTERS
FIBROBLASTS
GLUTATHIONE
IRRADIATION
MAMMALS
MAN
MEMBRANE TRANSPORT
ORGANIC COMPOUNDS
PATIENTS
PEPTIDES
POLYPEPTIDES
PRIMATES
PROTEINS
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RECOVERY
REPAIR
SOMATIC CELLS
VERTEBRATES