Origin of the rat mesangial phagocyte and its expression of the leukocyte common antigen
Journal Article
·
· Lab. Invest.; (United States)
OSTI ID:5969678
The authors have previously characterized a subpopulation of cells in the rat glomerular mesangium that are phagocytic, display Ia antigens, and stimulate lymphocytes. They now report that total-body irradiation induces a progressive loss of the Ia+ mesangial cells, which is complete by 3 days. Experiments utilizing kidney shielding and in vitro exposure to irradiation have established that the effect is not mediated via radiation sensitivity of the mesangial phagocyte. Transplantation of syngeneic bone marrow cells results in a restoration of Ia+ mesangial cells in 3 weeks, establishing their extrarenal origin. Employing monoclonal antibodies to rat leukocyte common (LC) antigen, a larger population of mesangial phagocytes has been quantified; the Ia+ cells are a subset of the glomerular LC+ cells. In tissue culture, anti-LC antibody labels 100% of the phagocytic cells obtained from perfused glomeruli. Ultrastructural analysis, utilizing immunoperoxidase techniques, has localized the LC+ cell to the glomerular mesangium.
- Research Organization:
- Harvard Medical School, Boston, MA
- OSTI ID:
- 5969678
- Journal Information:
- Lab. Invest.; (United States), Journal Name: Lab. Invest.; (United States) Vol. 51:5; ISSN LAINA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW CELLS
CELL CULTURES
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
EXTERNAL IRRADIATION
IMMUNE REACTIONS
IRRADIATION
KIDNEYS
LEUKOCYTES
MAMMALS
MATERIALS
MONOCLONAL ANTIBODIES
ORGANS
PHAGOCYTES
RADIATION EFFECTS
RATS
RODENTS
SOMATIC CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTIBODIES
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW CELLS
CELL CULTURES
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
EXTERNAL IRRADIATION
IMMUNE REACTIONS
IRRADIATION
KIDNEYS
LEUKOCYTES
MAMMALS
MATERIALS
MONOCLONAL ANTIBODIES
ORGANS
PHAGOCYTES
RADIATION EFFECTS
RATS
RODENTS
SOMATIC CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION