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Teratogenicity of 2,3,7,8-tetrachlorodibenzofuran in the mouse

Journal Article · · J. Toxicol. Environ. Health; (United States)
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2,3,7,8-Tetrachlorodibenzofuran (TCDBF) was administered in single doses (0.1-0.8 mg/kg body weight) intraperitoneally to pregnant C57BL mice on d 10, 11, 12, or 13 of gestation. A dose-dependent increase was observed in the frequency of fetal resorptions and fetal death, especially in the earlier stages (d 10-11). Cleft palate and hydronephrosis as well appeared in a dose-dependent manner, with a peak in sensitivity after administration on d 11-12. TCDBF given at a dose level of 0.1 mg/kg body weight on d 12 of gestation (only dose- and stage-tested) produced a marked thymic hypoplasia as well. A few cases of general hydrops occurred. The pattern of malformations and time of sensitivity corresponded well to that observed earlier after administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; ED50 approx. = 25 ..mu..g/kg) and 3,3',4,4'-tetrachloroazoxybenzene (TCAOB; ED50 approx. = 6 mg/kg), two congeners of TCDBF, indicating common mechanisms of action of this family of compounds. Ornithine decarboxylase (ODC) is an important enzyme in cell proliferation and growth with a high activity in embryonic tissues. Liver ODC activity has previously been found to be stimulated by TCDD in weanling mice. However, this enzyme was not found to be stimulated in fetal and placental tissues, but slightly in maternal kidney after treatment with TCDBF in teratogenic doses. It is possible that the ODC activity increases under certain conditions only, on administration of TCDD and its congeners. 40 references, 3 tables, 3 figures.

Research Organization:
Uppsala Univ., Sweden
OSTI ID:
5968508
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 14:2-3; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE GROUPS
ANIMALS
AROMATICS
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
CELL PROLIFERATION
CHLORINATED AROMATIC HYDROCARBONS
CONGENITAL MALFORMATIONS
DATA
DECARBOXYLASES
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ENZYME ACTIVITY
ENZYMES
EXPERIMENTAL DATA
FETAL MEMBRANES
FETUSES
GLANDS
GROWTH
HALOGENATED AROMATIC HYDROCARBONS
INFORMATION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
KIDNEYS
LIVER
LYASES
MALFORMATIONS
MAMMALS
MEMBRANES
MICE
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RODENTS
SENSITIVITY
TERATOGENESIS
VERTEBRATES