Comparative decontamination of hexachlorobenzene-exposed rats and rabbits by hexadecane

Journal Article · Sat Dec 31 23:00:00 EST 1983 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530585· OSTI ID:5968498

Scheufler, E; Rozman, K K

The effect of 8 wk of hexadecane (Hex; 5% w/w) in the diet on the disposition of /sup 14/C)hexachlorobenzene (HCB) was examined under identical conditions in rats and rabbits. Urine and feces were collected daily. Blood was obtained periodically. HCB was determined in serum, erythrocytes, heart, muscle, lungs, liver, kidney, spleen, fat, skin, and brain, as well as in excreta. The half-life of HCB was similar in the two species examined (rat 24 d; rabbit 32 d). Hex treatment increased by 4-5 fold the daily fecal excretion of HCB, resulting in correspondingly reduced half-lives of HCB in both species (rat 8 d, rabbits 12 d). As a result of Hex treatment, HCB concentrations in fat (major tissue of storage) of rabbits were about 5 times and in rats about 13 times lower than in corresponding controls. In general, the decrease of HCB in other tissues paralleled that in fat. Data indicate that the effect of Hex on the disposition of HCB is very similar in rats and rabbits. 13 references, 3 tables, 5 figures.

• Research Organization: Univ. of Kansas Medical Center, Kansas City
• OSTI ID: 5968498
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 14:2-3; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ALKANES
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD SERUM
BODY
BODY FLUIDS
BRAIN
CARBON 14 COMPOUNDS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CHLORINATED AROMATIC HYDROCARBONS
CLEANING
CLEARANCE
CONNECTIVE TISSUE
DATA
DECONTAMINATION
DIET
DIGESTIVE SYSTEM
DISTRIBUTION
ERYTHROCYTES
EXCRETION
EXPERIMENTAL DATA
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
HEART
HEXADECANE
HYDROCARBONS
INFORMATION
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MATERIALS
MUSCLES
NERVOUS SYSTEM
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RABBITS
RATS
RESPIRATORY SYSTEM
RETENTION
RODENTS
SKIN
SPLEEN
TISSUE DISTRIBUTION
TISSUES
TRACER TECHNIQUES
VERTEBRATES