Cocaine abstinence following chronic treatment alters cerebral metabolism in dopaminergic reward regions. Bromocriptine enhances recovery

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Neuropsychopharmacology; (USA)

OSTI ID:5962458

Clow, D W; Hammer, Jr, R P ^[1]

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1. Univ. of Hawaii School of Medicine, Honolulu (USA)

2-(14C)deoxyglucose autoradiography was used to determine local cerebral glucose utilization (lCGU) in rats following chronic cocaine treatment and subsequent abstinence. lCGU was examined in 43 discrete brain regions in animals which had received daily injections of cocaine for 14 days (10 mg/kg) followed by 3 days of saline or bromocriptine (10 mg/kg) treatment. Cocaine abstinence following chronic treatment significantly reduced lCGU in several regions including mesocorticolimbic structures such as ventral tegmental area, medial prefrontal cortex, and nucleus accumbens (NAc). Within the NAc, however, only the rostral pole showed significant reduction. In contrast, when bromocriptine treatment accompanied abstinence, lCGU was no longer reduced in mesocorticolimbic and most other regions, implying that metabolic recovery was enhanced by bromocriptine treatment during early abstinence following chronic cocaine treatment. These data suggest that cerebral metabolism is decreased during cocaine abstinence following chronic treatment in critical brain regions, and that this alteration can be prevented by treatment with direct-acting dopamine agonists such as bromocriptine.

• OSTI ID: 5962458
• Journal Information: Neuropsychopharmacology; (USA), Vol. 4:1; ISSN 0893-133X
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
COCAINE
BIOLOGICAL EFFECTS
ENZYME INHIBITORS
BIOCHEMICAL REACTION KINETICS
GLUCOSE
METABOLISM
AUTORADIOGRAPHY
CARBON 14 COMPOUNDS
CEREBRAL CORTEX
DOPAMINE
RATS
ALDEHYDES
ALKALOIDS
AMINES
ANESTHETICS
ANIMALS
ANTIDEPRESSANTS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CARBOHYDRATES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CEREBRUM
DRUGS
HEXOSES
HYDROXY COMPOUNDS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MONOSACCHARIDES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PSYCHOTROPIC DRUGS
REACTION KINETICS
RODENTS
SACCHARIDES
SYMPATHOMIMETICS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques