Experience with technetium-99m albumin colloid kit for reticuloendothelial system imaging

Journal Article · Mon Sep 01 04:00:00 EDT 1986 · J. Nucl. Med. Technol.; (United States)

OSTI ID:5962321

Saha, G B; Feiglin, D H.I.; O'Donnell, J K; Go, R T; Karam, P M; MacIntyre, W

The /sup 99m/Tc labeled albumin colloid has been evaluated regarding its particle size, both in vitro and in vivo stability, blood clearance, and efficacy in reticuloendothelial system imaging. The labeling efficiency was always > 99%. The labeled colloid remained stable both in vitro and in vivo for up to 24 hr. The blood clearance curve from four patients had two components: one with a T/sub 1/2/ of 2.48 +/- 0.37 min and the other with a T/sub 1/2/ of 271 +/- 109 min. Images of the liver, spleen, and bone marrow with /sup 99m/Tc-albumin colloid and /sup 99m/Tc-sulfur colloid showed a similar distribution pattern except that slightly higher splenic uptake relative to the liver was observed with the former. However, /sup 99m/Tc-albumin colloid has the advantage of easy preparation over /sup 99m/Tc-sulfur colloid.

• Research Organization: Cleveland Clinic Foundation, OH
• OSTI ID: 5962321
• Journal Information: J. Nucl. Med. Technol.; (United States), Journal Name: J. Nucl. Med. Technol.; (United States) Vol. 14:3; ISSN JNMTB
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
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62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
BODY
BONE MARROW
CLEARANCE
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
DRUGS
GLANDS
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
IN VITRO
IN VIVO
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOCOLLOIDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RETICULOENDOTHELIAL SYSTEM
SCINTISCANNING
SPLEEN
SULFUR COMPOUNDS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
TISSUES
YEARS LIVING RADIOISOTOPES