Characterization and physiologic regulation of atrial natriuretic factor receptors in rabbit preglomerular renal microvessels

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90495-W· OSTI ID:5961917

Chaudhari, A; Nakamura, S; Kirschenbaum, M A ^[1]

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1. Univ. of California, Irvine (USA)

There has been no direct demonstration of the presence of guanylate cyclase-linked atrial natriuretic factor receptors in renal preglomerular microvasculature. Using ({sup 125}I)ANF, we have demonstrated the presence of high affinity and low affinity ANF receptors in membranes derived from rabbit renal preglomerular microvessels (afferent arterioles and interlobular arteries). These microvessels also exhibited the presence of particulate bound ANF-sensitive guanylate cyclase. The density of the high affinity ANF receptor in desoxycorticosterone-treated rabbits on a high-salt diet was nearly half of that seen in rabbits on a normal diet. Data from this study demonstrated the presence of renal preglomerular ANF receptors and suggested that these receptors (perhaps in addition to glomerular ANF receptors) may participate in the regulation of extracellular volume.

• OSTI ID: 5961917
• Journal Information: Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 48:5; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AFFINITY
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL COMPOSITION
CYCLASES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LYASES
MAMMALS
MEMBRANE PROTEINS
MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
PROTEINS
RABBITS
RADIOISOTOPES
RECEPTORS
TRACER TECHNIQUES
VERTEBRATES