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Diagnosis of sclerosing cholangitis (SC) by Tc-99m-disida SPECT imaging

Conference · · J. Nucl. Med.; (United States)
OSTI ID:5961882
; ; ; ; ;
The role of planar scintigraphy and SPECT as a non-invasive imaging modality was assessed critically in the diagnosis of SC, a condition characterized by segmental narrowing and dilatation of intra and extra hepatic biliary ducts. Five normal subjects and 10 patients with cholangiographically documented SC were studied with 3 to 5 mCi of Tc-99m-DISIDA. Planar images were obtained. The tomographic images were reconstructed in transaxial, sagital and coronal planes. The tomo images and planar scintigraphy were then compared with cholangiograms to identify the exact sites of involvement. Tomo and planar scintigraphy showed homogeneous uptake and uniform excretion from all liver regions in normal subjects. In SC, the uptake was inhomogeneous and half-time excretion showed wide regional variation. SPECT images displayed dilated ducts as bile pooling and correctly identified ducts involved in the cholangiograms. The authors concluded that planar and SPECT scintigraphy offer a new non-invasive method for detection of SC and that the measurement of excretion half-time may offer a better objective parameter in following the course of therapy for SC.
Research Organization:
VA Medical Center
OSTI ID:
5961882
Report Number(s):
CONF-850611-
Conference Information:
Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
Country of Publication:
United States
Language:
English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BILIARY TRACT
CLEARANCE
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EXCRETION
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
PATIENTS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
TECHNETIUM ISOTOPES
TOMOGRAPHY
USES
YEARS LIVING RADIOISOTOPES