Whole body retention of Se-75-homotaurocholic acid (SeBCAT) using a Gamma Camera: A new test in chronic diarrhea
Bile acid malabsorption has been recognized as an important cause of chronic diarrhea. Se-75HCAT, a bile acid, is absorbed in the terminal ileum. Therefore, measurement of its body retention indicate ileal function not requiring fecal collections. The authors studied 8 normal volunteers presenting with chronic recurrent diarrhea for more than 2 years. Each received orally a 10 ..mu..Ci capsule of SeHCAT (Amersham Intl.) and 3 hours later anterior and posterior whole body activity was measured using a digital camera without collimator. Measurements were repeated daily for 7 days and expressed as % of retention. Three patients had normal retention (1 celiac disease, 1 inactive Crohn disease and 1 functional diarrhea), another was borderline (an immunodeficiency) and 4 patients presented abnormal bile acid absorption (2 had vagotomy, 1 Crohn disease and 1 idiopathic diarrhea). This last group was treated with cholestyramine showing improvement of the diarrhea, and relapse on drug withdrawal. These findings demonstrate that this technique can identify bile acid malabsorption as the cause of chronic diarrhea by external counting.
- Research Organization:
- Clinica Alemana, Clinica Las Condes
- OSTI ID:
- 5961773
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BILE ACIDS
BILIARY TRACT
CAMERAS
CARBOXYLIC ACIDS
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DIARRHEA
DIGESTION
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FUNCTIONS
GAMMA CAMERAS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLING
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RETENTION FUNCTIONS
SCINTISCANNING
SELENIUM 75
SELENIUM ISOTOPES
STEROIDS
STEROLS
SYMPTOMS
THERAPY
TISSUE DISTRIBUTION
USES