Lung uptake of Thallium-201 during atrial pacing stress: Hemodynamic determinants

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:5960923

Brown, K A; McKay, R; Heller, G V; Silverman, J; Aroesty, J; Grossman, W

Increased lung activity on Thallium-201 imaging during exercise stress testing has been shown to be related to left ventricular dysfunction in patients with coronary artery disease (CAD). This study was undertaken to more fully define the hemodynamic determinants of Thallium-201 lung uptake. In this investigation, 21 patients (6 normal, 15 CAD) were studied during graded tachycardia induced by atrial pacing with continuous hemodynamic monitoring. At peak pacing (end-point=85% predicted maximal heart rate or development of angina) 2.0 mCi Thallium-201 was injected IV and imaging initiated within 5 minutes. Lung activity was expressed as a percent of peak myocardial counts on the anterior image (lung Thallium-201 index). The influence of rest, peak, and post-pacing hemodynamic parameters, including pulmonary capillary wedge pressure (PCWP), cardiac index (CI), heart rate, and aortic pressure on lung Thallium-201 index was examined using step-wise multiple regression analysis. This study concludes that lung uptake of Thallium-201 during atrial pacing stress appears to depend on; hydrostatic pressure in the pulmonary capillary bed, and changes in cardiac output which may determine tissue contact time and influence extraction efficiency.

• Research Organization: Beth Israel Hospital, Harvard Medical School, Boston, MA 02114
• OSTI ID: 5960923
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORRELATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
EXERCISE
HEART
HEAVY NUCLEI
INHALATION
INTAKE
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
UPTAKE
USES