Rapid clearance of inhaled aerosols of Technetium-99M DTPA in patients with pneumocystis carinii pneumonia
Because infection with Pheumocystis carinii pneumonia (PCP) causes alteration of the type I epithelial cells as the primary event, the authors studied patients with PCP to determine if PCP causes rapid clearance of Tc-99m DTPA. Twenty normal non-smoking subjects and 7 non-smoking patients with histologically proven PCP were studied. Serial studies were obtained in three patients. Following a two-minute inhalation of 1.6 ..mu..m aerosol particles of Tc-99m DTPA in saline, the activity over three peripheral regions of interest (ROI) of each lung was monitored for the next 7 minutes. The rate of decline of activity over each ROI was expressed as per cent decline/min. In 7 patients with PCP, the average clearance was 7.5 +- 3.6% min., normal, 1.3 +- 0.6% min.(SD). Three patients studied from 5 to 38 days following therapy had improvement in the rate of clearance. This has been demonstrated to be persistent even after clinical recovery of the patient. The ability to quantitate injury to the pulmonary epithelium may directly reflect the ability of Pneumocystis carinii to invade the lung. The authors conclude that Tc-99m DTPA clearance may be a useful test to help diagnosis and monitor the activity of PCP infections.
- Research Organization:
- Harbor-UCLA Medical Center, Torrance, CA
- OSTI ID:
- 5960343
- Report Number(s):
- CONF-850611-; TRN: 87-039311
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
DTPA
LABELLING
LUNG CLEARANCE
LUNGS
RADIONUCLIDE KINETICS
PNEUMONIA
DIAGNOSIS
RADIOACTIVE AEROSOLS
DIAGNOSTIC USES
INHALATION
UPTAKE
TECHNETIUM 99
AIDS
CLEARANCE
EPITHELIUM
AEROSOLS
AMINO ACIDS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
COLLOIDS
DISEASES
DISPERSIONS
DRUGS
EXCRETION
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
INFECTIOUS DISEASES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SOLS
TECHNETIUM ISOTOPES
TISSUES
USES
VIRAL DISEASES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques