Absorption, tissue distribution, and excretion of tritium-labeled ivermectin in cattle, sheep, and rat

Journal Article · Thu Nov 01 04:00:00 EST 1990 · Journal of Agricultural and Food Chemistry; (USA)

DOI:https://doi.org/10.1021/jf00101a015· OSTI ID:5957192

Chiu, Shuething Lee; Green, M L; Baylis, F P; Eline, D; Rosegay, A; Meriwether, H; Jacob, T A ^[1]

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1. Merck Sharp and Dohme Research Laboratories, Rahway, NJ (USA)

Tritium-labeled ivermectin was studied in cattle, sheep, and rat for absorption, tissue residue distribution, and excretion at doses of 0.3 mg/kg of body weight. The drug was absorbed by various dosing routes. By intraruminal and subcutaneous dosing routes, highest tissue residues were present in fat and liver of cattle, with half-lives of 6-8 and 4-5 days, respectively. Shorter half-lives (1-2 days) were observed in sheep and rat. The tissue residue distribution pattern was essentially the same for all species studied and similar in male and female rats. With doses of tritium-labeled avermectin B{sub 1a} ranging from 0.06 to 7.5 mg/kg of body weight, plasma and tissue residue concentrations increased proportionally with the dose. When ivermectin was administered by various routes (ip, sc, iv, oral, and intraruminal), blood residue levels converged to 20-50 ppb 4 h after dosing and then depleted at similar rate regardless of the dosing route. Ivermectin was excreted primarily in the feces, with only less than 2% of the doses being eliminated in the urine in all three species studied.

• OSTI ID: 5957192
• Journal Information: Journal of Agricultural and Food Chemistry; (USA), Journal Name: Journal of Agricultural and Food Chemistry; (USA) Vol. 38:11; ISSN 0021-8561; ISSN JAFCA
• Country of Publication: United States
• Language: English

Related Subjects

553003* -- Agriculture & Food Technology-- Pest & Disease Control-- (1987-)
60 APPLIED LIFE SCIENCES
ABSORPTION
ANIMALS
ANTI-INFECTIVE AGENTS
CATTLE
CLEARANCE
COMPARATIVE EVALUATIONS
DISTRIBUTION
DOMESTIC ANIMALS
DRUGS
ESTERS
EXCRETION
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
LACTONES
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
PARASITES
RATS
RODENTS
RUMINANTS
SHEEP
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES