New role for gene linked to metastasis suppression
Journal Article
·
· Science (Washington, D.C.); (United States)
Researchers have discovered that one (H2) of two types of genes known as nm23 may be a transcription factor. nm23 was discovered six years ago to suppress metastasis in at least some types cancer. The nm23 H2 transcription factor is involved in regulation of the myc gene. It is unclear how an activator of myc could be involved in metastasis suppression, or how this activity relates to its nucleoside diphoshphate kinase activity. Since nm23 exists in two forms, it is possible that only one form, H1, is involved in metastasis suppression.
- OSTI ID:
- 5957140
- Journal Information:
- Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 251:5120; ISSN SCIEAS; ISSN 0036-8075
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550400* -- Genetics
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
CLONING
DISEASES
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
ENZYMES
GENE REGULATION
GENES
HYBRIDIZATION
INHIBITION
METASTASES
NEOPLASMS
NUCLEOTIDES
ONCOGENES
ORGANIC COMPOUNDS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
TRANSCRIPTION FACTORS
TRANSFERASES
550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
CLONING
DISEASES
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
ENZYMES
GENE REGULATION
GENES
HYBRIDIZATION
INHIBITION
METASTASES
NEOPLASMS
NUCLEOTIDES
ONCOGENES
ORGANIC COMPOUNDS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS
TRANSCRIPTION FACTORS
TRANSFERASES